Gene information
Official symbol TIMP2
Official full name TIMP metallopeptidase inhibitor 2
Gene type protein-coding gene
Chromosome17q25.3
Alias symbolCSC-21K
Gene familyTissue inhibitor of metallopeptidases
Resources
Entrez Gene 7077
HGNC HGNC:11821
Ensembl ENSG00000035862
Vega OTTHUMG00000154517
UCSC uc002jwf.4
GO terms: 35 records
GO Description Category LogP Number of genes Detail
GO:0002020 protease binding GO Molecular Functions -28.8254555 31 More
GO:0004857 enzyme inhibitor activity GO Molecular Functions -18.4005452 35 More
GO:0004866 endopeptidase inhibitor activity GO Molecular Functions -20.0646267 27 More
GO:0008191 metalloendopeptidase inhibitor activity GO Molecular Functions -5.83914312 5 More
GO:0009725 response to hormone GO Biological Processes -49.1091700 138 More
GO:0009895 negative regulation of catabolic process GO Biological Processes -10.3621088 43 More
GO:0010466 negative regulation of peptidase activity GO Biological Processes -24.1438543 35 More
GO:0010951 negative regulation of endopeptidase activity GO Biological Processes -24.7873219 35 More
GO:0030162 regulation of proteolysis GO Biological Processes -41.2267045 73 More
GO:0030312 external encapsulating structure GO Cellular Components -73.3689453 93 More
GO:0030414 peptidase inhibitor activity GO Molecular Functions -19.6181890 27 More
GO:0031012 extracellular matrix GO Cellular Components -73.4416071 93 More
GO:0031330 negative regulation of cellular catabolic process GO Biological Processes -6.88355184 32 More
GO:0031983 vesicle lumen GO Cellular Components -60.5757669 68 More
GO:0034774 secretory granule lumen GO Cellular Components -58.3093741 66 More
GO:0035580 specific granule lumen GO Cellular Components -14.6396218 15 More
GO:0042176 regulation of protein catabolic process GO Biological Processes -8.45353494 23 More
GO:0042177 negative regulation of protein catabolic process GO Biological Processes -5.18322511 10 More
GO:0042581 specific granule GO Cellular Components -15.6202777 22 More
GO:0043086 negative regulation of catalytic activity GO Biological Processes -41.1437610 130 More
GO:0045861 negative regulation of proteolysis GO Biological Processes -27.9905009 43 More
GO:0051043 regulation of membrane protein ectodomain proteolysis GO Biological Processes -16.3022563 12 More
GO:0051045 negative regulation of membrane protein ectodomain proteolysis GO Biological Processes -7.69370672 5 More
GO:0051346 negative regulation of hydrolase activity GO Biological Processes -26.0030636 42 More
GO:0052547 regulation of peptidase activity GO Biological Processes -35.5643317 55 More
GO:0052548 regulation of endopeptidase activity GO Biological Processes -34.9486589 53 More
GO:0060205 cytoplasmic vesicle lumen GO Cellular Components -59.3932782 67 More
GO:0061134 peptidase regulator activity GO Molecular Functions -19.3582235 29 More
GO:0061135 endopeptidase regulator activity GO Molecular Functions -19.1908633 27 More
GO:0062023 collagen-containing extracellular matrix GO Cellular Components -67.6170082 80 More
GO:0070820 tertiary granule GO Cellular Components -12.1965297 19 More
GO:0101002 ficolin-1-rich granule GO Cellular Components -6.76434995 14 More
GO:1904724 tertiary granule lumen GO Cellular Components -12.6232675 13 More
GO:1904813 ficolin-1-rich granule lumen GO Cellular Components -6.12299383 11 More
GO:1905049 negative regulation of metallopeptidase activity GO Biological Processes -7.64224943 8 More
Related studies: 5 records
Molecular factor Omics type Application Objective MI type Reference
metalloproteinase inhibitor 2 proteomics doxycycline[treatment (pharmacotherapy)] acute ST elevation myocardial infarction Cerisano G et al. Int J Cardiol. 2015
metalloproteinase inhibitor 2 proteomics adverse events[prognosis (bad)] acute ST elevation myocardial infarction Cerisano G et al. Int J Cardiol. 2015
NM_003255.5:c.-4804T>G genomics hypertension[prognosis (bad)] myocardial infarction Rodriguez-Perez JM et al. J Genet. 2014
NM_003255.5:c.-2803T>C genomics hypertension[prognosis (bad)] myocardial infarction Rodriguez-Perez JM et al. J Genet. 2014
metalloproteinase inhibitor 2 proteomics poor predictor major adverse cardiovascular events[prognosis (bad)] acute myocardial infarction Kelly D et al. Am J Cardiol. 2010
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